Creatine metabolism in skeletal muscle of noradrenaline-treated rats

Prolonged noradrenaline treatment did not affect the urinary creatine excretion, creatine radioactivity, and the creatine contents of all muscles studied. Radioactive creatine uptake by skeletal muscle was significantly lower in noradrenaline-treated rats than in controls, while those by heart and diaphragm were not affected by noradrenaline.