Mucosal adherence of human enteropathogenic Escherichia coli

An in-vitro assay system has been developed to measure bacterial adhesion to the mucosa of human fetal small intestine. Two strains of Escherichia coli that are proven human enteropathogens (E.P.E.C.) have been shown to adhere in large numbers, compared with control organisms. The attachment mechanism is species specific and is not caused by common fimbriae. Mucosal adhesion may be as important as enterotoxin production or invasiveness in determining the virulence of some strains of human E.P.E.C.