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Updated: Aug 9, 2026
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Aortic Ring Assay
Published on: November 24, 2009
A clinical service for prenatal diagnosis
Lancet (London, England)
|November 15, 1975
Summary
Prenatal diagnosis through amniocentesis identified genetic abnormalities and fetal defects in 174 patients. This service aided in pregnancy termination decisions for severe conditions, improving prenatal care outcomes.
Area of Science:
- Medical Genetics
- Prenatal Diagnostics
Background:
- Established a centralized clinical prenatal diagnostic service.
- Reviewed 174 amniocentesis cases.
Purpose of the Study:
- Evaluate the efficacy of a centralized prenatal diagnostic service.
- Analyze outcomes of amniocentesis in a clinical setting.
Main Methods:
- Amniocentesis performed on 174 patients.
- Genetic analysis for cytogenetic abnormalities.
- Alpha-fetoprotein and ultrasound for fetal anomalies.
Main Results:
- Pregnancy termination in 3 cases due to cytogenetic abnormalities (Klinefelter, Triple X, Trisomy 21).
- Termination in 2 cases with anencephalic fetuses and 1 with Hurler's syndrome.
- Amniotic fluid cell culture failure in 9/155 cases; 2 failures unexplained. One fetal sex determination error.
Conclusions:
- Centralized prenatal diagnostics effectively identify fetal abnormalities.
- Amniocentesis is a valuable tool for informed pregnancy management.
- Service demonstrated utility in detecting chromosomal and structural fetal defects.
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