Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immune complexes and complement in rheumatoid arthritis.

P H Lambert, P Casali, U Nydegger

    Bulletin Der Schweizerischen Akademie Der Medizinischen Wissenschaften
    |September 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Streamlining clinical research: an ESMO awareness call to improve sponsoring and monitoring of clinical trials.

    Annals of oncology : official journal of the European Society for Medical Oncology·2022
    Same author

    European Reference Network for rare adult solid cancers, statement and integration to health care systems of member states: a position paper of the ERN EURACAN.

    ESMO open·2021
    Same author

    Safety and immunogenicity of the epicutaneous reactivation of pertussis toxin immunity in healthy adults: a phase I, randomized, double-blind, placebo-controlled trial.

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2020
    Same author

    Impact of chemotherapy in uterine sarcoma (UtS): review of 13 clinical trials from the EORTC Soft Tissue and Bone Sarcoma Group (STBSG) involving advanced/metastatic UtS compared to other soft tissue sarcoma (STS) patients treated with first line chemotherapy.

    Gynecologic oncology·2016
    Same author

    Making the immune system work.

    Immunology today·2014
    Same author

    Kinetics and calcium-specificity of polyamine uptake in carrot protoplasts.

    Amino acids·2013
    Same journal

    About the adrenergic functions on the heart and vessels.

    Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften·2010
    Same journal

    Subcutaneous depetoxycorticosterone acetate deposit in a case of adrenal insufficiency.

    Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften·2010
    Same journal

    Family osteogenesis imperfecta (type Vrolik) and its treatment with vitamin D shock.

    Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften·2010
    Same journal

    Verification of the law of projection of the electrical potentials of the heart on the surface of the human body.

    Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften·2010
    Same journal

    About the osmotic mechanism of the plant cell.

    Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften·2010
    Same journal

    From the higher centers of the vegetative function system.

    Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften·2010
    See all related articles

    Immune complexes are prevalent in rheumatoid arthritis, contributing to inflammation and vascular lesions. Their analysis, along with complement components, aids in diagnosis and understanding this autoimmune disease.

    Area of Science:

    • Rheumatology
    • Immunology
    • Pathogenesis of autoimmune diseases

    Background:

    • Immune complexes are frequently observed in rheumatoid arthritis (RA) patients.
    • They are detected in blood, synovium, and extravascular sites.
    • Recent advancements allow for immune complex quantitation, aiding research into their role in RA.

    Purpose of the Study:

    • To evaluate the role of immune complexes in rheumatoid arthritis pathogenesis.
    • To investigate the characteristics and formation of immune complexes in synovial fluid.
    • To explore the link between immune complexes, complement activation, and disease activity.

    Main Methods:

    • Quantitation of immune complexes in serum and synovial fluid.
    • Analysis of physicochemical properties of immune complexes.

    Related Experiment Videos

  • Assessment of complement activation and breakdown products in biological fluids.

    • Main Results:

    • Immune complexes in synovial fluid exhibit higher concentrations and distinct properties compared to serum.
    • Local formation of immune complexes in the synovium appears to drive inflammation.
    • Elevated circulating immune complexes correlate with extra-articular vascular lesions.
    • Evidence of complement activation is present in RA patients' blood and synovial fluid.
    • Complement breakdown product levels correlate with clinical disease activity.

    Conclusions:

    • Immune complexes play a significant role in rheumatoid arthritis pathogenesis, particularly in local inflammation and extra-articular manifestations.
    • Complement system activation by immune complexes is a key feature of RA.
    • Analyzing immune complexes and complement components is valuable for RA diagnosis, monitoring, and understanding disease mechanisms.