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Intravesical lignocaine and detrusor instability.
British Journal of Urology
|December 1, 1979
Summary
Intravesical lignocaine solution improved bladder capacity and reduced detrusor pressure in patients with detrusor instability. However, symptomatic relief was temporary for most participants, lasting only 24 hours in one case.
Area of Science:
- Urology
- Pharmacology
Background:
- Detrusor instability is a common cause of lower urinary tract symptoms.
- Current treatments for detrusor instability have limitations.
- Intravesical lignocaine is a potential therapeutic agent.
Purpose of the Study:
- To evaluate the efficacy of intravesical lignocaine solution in patients with detrusor instability of mixed aetiology.
Main Methods:
- Twenty patients with detrusor instability received intravesical instillation of 40 ml of 1% lignocaine solution mixed with 40 ml of 8.4% sodium bicarbonate solution.
- Bladder capacity, sensation, cystometrogram characteristics, and maximum detrusor pressure were assessed.
Main Results:
- Nineteen patients showed increased bladder capacity.
- Sixteen patients experienced a reduction in maximum detrusor pressure during bladder filling.
- Altered bladder sensation and cystometrogram characteristics were observed in nine patients each.
- Symptomatic improvement was transient, lasting up to 24 hours in one patient.
Conclusions:
- Intravesical lignocaine demonstrates a temporary inhibitory effect on bladder function in patients with detrusor instability.
- Further research is warranted to explore the mechanisms and potential for sustained therapeutic effects.