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Pericarditis in acute myocardial infarction.

K L Liem, D Durrer, K I Lie

    Lancet (London, England)
    |November 22, 1975
    PubMed
    Summary

    Pericarditis occurred in 14.7% of acute myocardial infarction survivors. It did not worsen prognosis, suggesting anticoagulants should continue, especially with atrial fibrillation.

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    Area of Science:

    • Cardiology
    • Internal Medicine

    Background:

    • Acute myocardial infarction (AMI) is a leading cause of cardiovascular mortality.
    • Post-myocardial infarction pericarditis is a known complication, but its incidence and prognostic impact require further elucidation.

    Purpose of the Study:

    • To determine the incidence of pericarditis in patients surviving the initial 24 hours of acute myocardial infarction.
    • To identify factors associated with pericarditis following acute myocardial infarction.
    • To evaluate the impact of pericarditis on immediate prognosis and cardiac rupture incidence.

    Main Methods:

    • Prospective study involving 300 consecutive patients who survived the first 24 hours of acute myocardial infarction.
    • Data collection included patient characteristics, myocardial infarction details, and clinical outcomes.
    • Statistical analysis identified independent factors associated with pericarditis.

    Main Results:

    • Pericarditis was observed in 44 patients (14.7%).
    • Independent predictors of pericarditis included transmural myocardial infarction, extent of myocardial damage, atrial fibrillation, and prolonged fever duration.
    • Pericarditis did not significantly affect immediate prognosis or the incidence of cardiac rupture.

    Conclusions:

    • The incidence of pericarditis post-acute myocardial infarction is significant.
    • Atrial fibrillation is a key associated factor, highlighting the need for careful management.
    • Discontinuation of anticoagulant therapy in patients with pericarditis complicating acute myocardial infarction is not recommended due to favorable prognosis.

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