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[Triglycerides, fatty acids and cortisol in simple obesity in children]
Insights
Childhood obesity (obesitas simplex) does not show significant differences in triglycerides, free fatty acids, or cortisol levels compared to healthy children. Metabolic adaptational mechanisms may explain these findings during growth and development.
Area of Science:
- Pediatric Endocrinology
- Metabolic Disorders
- Child Health
Background:
- Childhood obesity, or obesitas simplex, is a growing concern.
- Understanding metabolic profiles in obese children is crucial for health management.
Purpose of the Study:
- To investigate serum levels of triglycerides (TG), free fatty acids (FFA), and cortisol (F) in children with obesitas simplex.
- To compare these levels between obese children and healthy controls, and between different age groups of obese children.
Main Methods:
- Serum samples were collected from 50 children aged 6-14 years diagnosed with obesitas simplex.
- Participants were categorized into younger and older age groups based on developmental stage.
- TG, FFA, and F levels were measured and compared between obese children, healthy controls, and within obese subgroups.
Main Results:
- Mean concentrations of TG, FFA, and cortisol in obese children were within normal ranges.
- No statistically significant differences were observed in these parameters between obese children and healthy controls.
- No significant differences were found when comparing younger and older obese children, nor were interrelationships found between birth weight, obesity duration, and TG levels.
Conclusions:
- Obesitas simplex in children does not appear to cause detectable disturbances in serum TG, FFA, and cortisol levels.
- Efficient metabolic adaptational mechanisms during growth and development may contribute to maintaining normal levels despite overfeeding.
Abstract:
In 50 children with obesitas simplex, 6-14 years of age, the triglycerides (TG), free fatty acids (FFA) and cortisol (F) levels in venous blood serum were estimated. In agreement with the development stages, studied patients were divided into the group of younger children in prematurity stage and the group of older children approaching the maturity. Obtained mean values of TG, FFA and F concentrations were analysed in the particular groups of obese children and compared with the healthy children of the same age. Mean concentrations of TG, FFA and cortisol in obese children were within the normal values and statistically did not differ from those of control healthy children. Also there was no difference in parameters studied if compared the younger and older groups of obese children. There was no interrelationship between the high birth weight and the degree of overweight as well as between the duration of obesity and the blood serum TG levels. In the course of obesitas simplex in children no detectable disturbances in the levels of TG, FFA and cortisol were found. It may depends on the more efficient adaptational mechanism connected with metabolism which are acting in the course of overfeed in the period of growth and development.