[Treatment of therapy resistant depressions with high dose clomipramine]

50 so-called therapy-resistant depressed inpatients have been treated with daily i.v. infusions of Clomipramine in a high dosage, using a fixed therapy schedule with increasing and decreasing dosage ranging from 250 to 500 mg. The majority of the inpatients showed sufficient or good therapeutic effects, notable side effects were rare. The therapeutic possibilities of so-called therapy-resistant depressions are discussed.