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Related Experiment Videos

Abnormal embryogenesis induced by thiopental.

A D Novitt, S H Gilani

    Journal of Clinical Pharmacology
    |November 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Thiopental administration to developing chick embryos can cause significant malformations. This study found dose-dependent teratogenic effects, highlighting potential risks in avian development.

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    Area of Science:

    • Developmental toxicology
    • Avian embryology

    Background:

    • Thiopental is a widely used anesthetic.
    • Understanding its effects on embryonic development is crucial for safety assessments.

    Purpose of the Study:

    • To investigate the teratogenic potential of thiopental in chick embryos.
    • To determine the lethal dose 50 (LD50) of thiopental at different embryonic stages.

    Main Methods:

    • Thiopental was injected into the air sacs of embryonating chicken eggs (days 2-4 of incubation).
    • Doses ranged from 0.2 to 4.0 mg per egg, with saline controls.
    • A total of 1080 eggs were used, with embryos examined on day 7.

    Main Results:

    • The LD50 varied by injection day: 2.1 mg (day 2), 1.9 mg (day 3), and 4.1 mg (day 4).

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  • Observed malformations included exencephaly, anencephaly, limb and neck twisting, microphthalmia, everted viscera, and hemorrhages.

    • Conclusions:

    • Thiopental exhibits teratogenic effects in chick embryos.
    • The study indicates a clear tendency for thiopental to induce developmental abnormalities.