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Airway responsiveness in workers processing polyester resins.

E Zuskin, M Saric, A Bouhuys

    Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association
    |December 1, 1979
    PubMed
    Summary
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    Polyester resin exposure acutely reduced lung function in workers. The autonomic nervous system influences this response, with propranolol worsening and atropine improving symptoms, suggesting a role in polyester resin-induced bronchoconstriction.

    Area of Science:

    • Occupational Medicine
    • Pulmonary Physiology
    • Environmental Health

    Background:

    • Polyester resins are used in various industries, including button manufacturing.
    • Occupational exposure to industrial chemicals can lead to respiratory issues.
    • The role of the autonomic nervous system in chemical-induced bronchoconstriction requires further investigation.

    Purpose of the Study:

    • To investigate the acute effects of polyester resin exposure on respiratory function in manufacturing plant employees.
    • To determine the influence of the autonomic nervous system on polyester resin-induced airway responses.
    • To assess the prevalence of acute and chronic respiratory symptoms in exposed workers.

    Main Methods:

    • Studied 22 employees in a button-manufacturing plant over an eight-hour work shift.

    Related Experiment Videos

  • Measured changes in maximum expiratory flow volume (MEFV) curves, specifically at MEF50% and MEF25%.
  • Administered propranolol (80 mg) and atropine (1 mg) preshift to assess autonomic nervous system involvement.
  • Main Results:

    • Exposure to polyester resins caused an acute reduction in MEFV flow rates (MEF50% and MEF25%).
    • Preshift propranolol potentiated the bronchoconstricting effect, while atropine significantly inhibited it.
    • High prevalence of acute symptoms (cough, shortness of breath, irritation) reported, but no significant chronic respiratory symptoms or obstruction were found.

    Conclusions:

    • Polyester resin exposure can lead to acute reductions in lung function.
    • The autonomic nervous system plays a significant role in mediating airway smooth muscle responses to polyester resins.
    • While acute symptoms are common, current evidence does not indicate a high prevalence of chronic respiratory issues or obstruction from this exposure.