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Comparative pathogenicity of Actinomyces naeslundii and Actinomyces israelii
Abstract:
Typical actinomycosis has been produced in mice following single intraperitoneal injections of saline suspensions of Actinomyces israelii and A. naeslundii. A. israelii produced infections in 95.8% of the animals inoculated. A. naeslundii, generally considered to be a saprophytic organism, produced lesions in 89.7% of the inoculated animals. The finding that A. naeslundii produced lesions in mice similar to those produced by A. israelii suggests that A. naeslundii has similar pathogenic potential for man. The isolation of A. naeslundii from suppurative lesions of man also supports this conclusion.
Insights
Actinomyces israelii and Actinomyces naeslundii can cause actinomycosis in mice. Actinomyces naeslundii, often seen as non-pathogenic, demonstrated significant lesion development, suggesting similar human pathogenic potential.
Area of Science:
- Microbiology
- Infectious Diseases
- Animal Models
Background:
- Actinomycosis is a bacterial infection.
- Actinomyces israelii is a known causative agent of actinomycosis.
- Actinomyces naeslundii is typically considered a commensal or saprophytic organism.
Purpose of the Study:
- To investigate the pathogenic potential of Actinomyces naeslundii in a murine model.
- To compare the pathogenicity of Actinomyces israelii and Actinomyces naeslundii.
Main Methods:
- Induction of actinomycosis in mice via intraperitoneal injection.
- Use of Actinomyces israelii and Actinomyces naeslundii suspensions.
- Observation and documentation of lesion development.
Main Results:
- Actinomyces israelii caused infections in 95.8% of mice.
- Actinomyces naeslundii induced lesions in 89.7% of inoculated mice.
- Lesions produced by A. naeslundii were similar to those caused by A. israelii.
Conclusions:
- Actinomyces naeslundii exhibits significant pathogenic potential in mice.
- Findings suggest Actinomyces naeslundii may also be pathogenic in humans.
- Supports previous isolations of A. naeslundii from human suppurative lesions.