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[Children typhoid fever in Saigon (Vietnam) : epidemiological and biological aspects (author's transl)]
Insights
This review of pediatric typhoid fever in Vietnam found frequent thrombocytopenia and common antibiotic resistance in Salmonella Typhi strains. Most S. typhi exhibited plasmid resistance to multiple antibiotics, unlike other intestinal bacteria.
Area of Science:
- Pediatric Infectious Diseases
- Microbiology
- Clinical Medicine
Context:
- Review of 130 children diagnosed with typhoid fever in Saigon, Vietnam.
- Focuses on clinical manifestations, diagnostic findings, and antimicrobial resistance patterns.
- Highlights the prevalence of thrombocytopenia and antibiotic resistance in pediatric typhoid cases.
Purpose:
- To analyze clinical and microbiological features of typhoid fever in children in Saigon.
- To investigate the frequency of thrombocytopenia and the antibiotic resistance profiles of Salmonella Typhi.
- To compare antibiotic resistance between S. Typhi and other enterobacteria.
Summary:
- Thrombocytopenia was a frequent finding in pediatric typhoid fever cases.
- Salmonella Typhi (S. typhi) was typically isolated from blood within the first two weeks.
- Most S. typhi strains showed plasmid-mediated resistance to streptomycin, chloramphenicol, tetracycline, and sulfamides.
- Other enterobacteria from the intestinal flora displayed broader antibiotic resistance compared to S. typhi.
Impact:
- Provides insights into the clinical presentation and laboratory findings of typhoid fever in Vietnamese children.
- Documents significant antibiotic resistance in S. Typhi, impacting treatment strategies.
- Underscores the need for ongoing surveillance of antimicrobial resistance in pediatric infectious diseases.
Abstract:
A review of 130 children cases of typhoid fever in Saigon (Vietnam). Leuco-neutropenia is far from regular but thrombopenia is frequent. The typhoid bacillus is generally cultivated from blood during the first two weeks of the evolution. There is evidence in most S. typhi strains of a plasmid resistance for streptomycine, chloramphenicol, tetracycline and sulfamides. Strains of the various other enterobacteria of the intestinal flora are generally resistant for many more antibiotics than S. typhi.