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Acquired, transient factor X (Stuart factor) deficiency in patient with mycoplasma pneumonial infection
Abstract:
A case of severe haemorrhagic diathesis due to acquired deficiency of factor X (both immunologically and in procoagulant activity) is presented. The clinical and serological features of this case indicated mycoplasma pneumonial infection. Factor X in the peripheral blood did not appear to be influenced by administration of vitamin K, prothrombin-complex concentrate, fresh plasma or fresh whole blood. Circulating inhibitors of blood coagulation were absent and systemic amyloidosis could not be demonstrated. After 20 d, factor X spontaneously returned to normal. In view of the absence of other known causes of factor X deficiency, a possible relationship with mycoplasma pneumonial infection is suggested.
Insights
A rare case of acquired factor X deficiency causing severe bleeding was linked to Mycoplasma pneumoniae infection. Factor X levels normalized spontaneously after 20 days without specific treatment.
Area of Science:
- Hematology
- Infectious Diseases
Background:
- Acquired factor X deficiency is a rare bleeding disorder.
- Mycoplasma pneumoniae infections are common respiratory illnesses.
Observation:
- A patient presented with severe hemorrhagic diathesis due to acquired factor X deficiency.
- Clinical and serological findings suggested a Mycoplasma pneumoniae infection.
Findings:
- Factor X levels were unresponsive to vitamin K, prothrombin-complex concentrate, fresh plasma, or whole blood.
- No circulating inhibitors or systemic amyloidosis were detected.
- Factor X levels spontaneously normalized within 20 days.
Implications:
- This case suggests a potential association between Mycoplasma pneumoniae infection and acquired factor X deficiency.
- Further research is needed to elucidate the mechanism of this association.
- This finding may inform diagnostic and therapeutic approaches in similar cases.