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Related Experiment Videos

[Liver involvement in lymphogranulomatosis].

P Hanke, W Sickel, L Stenzel

    Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete
    |July 15, 1979
    PubMed
    Summary

    Biochemical markers can help detect liver infiltration in lymphogranulomatosis. Elevated levels of alkaline phosphatase (AP), gamma-glutamyl transpeptidase (GGTP), and lactate dehydrogenase (LDH) indicate liver involvement with 85% accuracy.

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    Area of Science:

    • Biochemistry
    • Oncology
    • Hepatology

    Context:

    • Lymphogranulomatosis, a type of lymphoma, can affect various organs.
    • Liver infiltration is a significant complication in patients with lymphogranulomatosis.
    • Accurate diagnosis of liver involvement is crucial for effective treatment planning.

    Purpose:

    • To evaluate the diagnostic value of various biochemical parameters for detecting liver infiltration in lymphogranulomatosis.
    • To identify specific enzyme markers that indicate hepatic affection.
    • To determine the predictive accuracy of these markers for liver involvement.

    Summary:

    • This study analyzed biochemical parameters in 146 patients with lymphogranulomatosis to assess liver infiltration.
    • Significantly elevated levels of alkaline phosphatase (AP), gamma-glutamyl transpeptidase (GGTP), alpha-1-antitrypsin (AAP), leucine aminopeptidase (LAP), and lactate dehydrogenase (LDH) were observed in patients with confirmed liver involvement.
    • An increase in four specific enzyme values predicted liver participation with 85% probability.

    Impact:

    • Identifies key biochemical markers for non-invasive detection of liver infiltration in lymphogranulomatosis.
    • Provides a probabilistic diagnostic tool for clinicians managing these patients.
    • Excludes certain enzymes (SGOT, SGPT, GDH, LDH-isoenzymes, choline esterase, beta-GC, De Ritis quotient) from providing additional differential-diagnostic information for liver involvement.

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