[Hyperuricaemia--a parameter in the prognosis of gestosis (author's transl)]

The level of uric acid is considered to be of prognostic value regarding gestosis and condition of the fetus. Serum concentration of uric acid is influenced by sex, age and, during pregnancy, by gestational age. In order to get a sound basis for correlations in gestosis we collected data of normal gravidae in different weeks of gestation: in the mean values there was an increase of uric acid concentration from 2,03 mg/100 ml up to 3,54 mg/100 ml (from the first week of gestation up to the end of gestation). In gravidae with gestosis (according to Gestosis Index recommended by Geocke) the mean values were found to be between 2,71 mg/100 ml and 7,54 mg/100 ml. In gravidae with gestosis and intrauterine fetal death during II. and III. trimenon the mean values of uric acid were found between 5,05 mg/100 ml and 9,91 mg/100 ml. In clinical routine we proofed the estimation of uric acid concentration as a prognostic aspect in gestosis and especially by serial estimations and furthermore there is a possibility to study therapeutical effects. In a pilot study we try to use the estimation of uric acid concentration as an early symptom of gestosis.