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[Ultrastructural study of Mibelli's porokeratosis. Pathogenic and therapeutic considerations in three cases]
Abstract:
Report of three cases of porokeratosis Mibelli with emphasis on the ultrastructural changes of the entire epidermis underlying the cornoid lamella: autophagocytosis, filamentous degeneration, formation of "corps ronds". These phenomena are correlated with those of apoptosis (or intraepidermal cellular death with filamentous degeneration). Its role in the genesis of the cornoid lamella and in the degeneration of the lesions is discussed. In conclusion, on the basis of the reported observations and of the studies showing the action of retinoic acid and its derivatives on precancerous lesions, the authors propose to treat the actinic disseminated form of porokeratosis Mibelli with the aromatic derivative of retinoic acid (RO 10 9359).
Insights
This study details ultrastructural changes in porokeratosis Mibelli, revealing cellular degeneration linked to apoptosis. Researchers propose treating disseminated actinic porokeratosis Mibelli with a retinoic acid derivative.
Area of Science:
- Dermatology
- Cell Biology
- Histopathology
Background:
- Porokeratosis Mibelli is a rare keratinization disorder.
- Understanding its cellular mechanisms is crucial for effective treatment.
Observation:
- Three cases of Porokeratosis Mibelli were examined for ultrastructural changes.
- Key changes included autophagocytosis, filamentous degeneration, and corps ronds formation in the epidermis beneath the cornoid lamella.
Findings:
- These ultrastructural phenomena correlate with apoptosis (intraepidermal cellular death).
- The study discusses the role of these changes in cornoid lamella genesis and lesion degeneration.
Implications:
- The findings suggest a cellular basis for lesion development in Porokeratosis Mibelli.
- A retinoic acid derivative (RO 10 9359) is proposed for treating the actinic disseminated form, based on its effects on precancerous lesions.