Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Immune mechanisms in uremia].

H Dobbelstein

    Klinische Wochenschrift
    |May 15, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Patients with renal insufficiency exhibit suppressed cellular and humoral immunity. Complex mechanisms like lymphopenia and toxic serum factors contribute to this natural immunosuppression, though their exact roles remain unclear.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Increased renal retention values in general practice. Creatinine and urea too high--what should be done].

    MMW Fortschritte der Medizin·2002
    Same author

    [Background of a toxicological emergency: homicide attempt with monk's hood].

    MMW Fortschritte der Medizin·2000
    Same author

    [Physicians' quality circles].

    Versicherungsmedizin·2000
    Same author

    [Acute renal failure resulting from hemoglobinuria in the Zieve syndrome].

    MMW, Munchener medizinische Wochenschrift·1981
    Same author

    [A new device for humane rat control].

    Das Offentliche Gesundheitswesen·1979
    Same author

    [Immunsuppression by vitamin B6-antagonists. Prolonged survival of inbred rats with renal transplants (author's transl)].

    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie·1979
    Same journal

    Klinische Wochenschrift·2020
    Same journal

    Pathological anatomy of malnutrition.

    Klinische Wochenschrift·2010
    Same journal

    Consequences of chronic malnutrition in the clinical picture of internal diseases.

    Klinische Wochenschrift·2010
    Same journal

    Use of stable isotopes in biology.

    Klinische Wochenschrift·2010
    Same journal

    About applications of radioactive indicators in medicine and physiology.

    Klinische Wochenschrift·2010
    Same journal

    Early diagnosis and assessment of the activity of pulmonary tuberculosis based on serological examinations.

    Klinische Wochenschrift·2010
    See all related articles

    Area of Science:

    • Immunology
    • Nephrology
    • Transplantation

    Background:

    • Clinical and experimental evidence indicates immune suppression in renal insufficiency.
    • Uremia is associated with impaired immune responses, affecting both cellular and humoral immunity.

    Purpose of the Study:

    • To review the evidence for immune suppression in renal insufficiency.
    • To discuss potential underlying mechanisms of this immunosuppression.

    Main Methods:

    • Review of clinical and experimental data.
    • Analysis of studies on organ transplantation, lymphocyte function, hypersensitivity reactions, and immune responses in uremic patients.

    Main Results:

    • Renal insufficiency is linked to suppressed cellular and humoral immunity.

    Related Experiment Videos

  • Observed changes include lymphopenia, thymus atrophy, toxic serum factors, and lymphocyte metabolic defects.

    • Conclusions:

    • The mechanisms of immune suppression in renal insufficiency are complex and multifactorial.
    • While several factors are implicated, their precise contribution to "natural immunosuppression" in uremia requires further investigation.