Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Piracetam in chronic brain failure.

S Lloyd-Evans, J C Brocklehurst, M K Palmer

    Current Medical Research and Opinion
    |January 1, 1979
    PubMed
    Summary

    Piracetam did not significantly improve cognitive function in patients with chronic brain failure over a 6-week treatment period. The study found no substantial evidence to support piracetam

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Comparison of the effects of different statins and doses on lipid levels in patients with diabetes: results from VOYAGER.

    Nutrition, metabolism, and cardiovascular diseases : NMCD·2012
    Same author

    Increased age, high body mass index and low HDL-C levels are related to an echolucent carotid intima-media: the METEOR study.

    Journal of internal medicine·2011
    Same author

    Manual or semi-automated edge detection of the maximal far wall common carotid intima-media thickness: a direct comparison.

    Journal of internal medicine·2011
    Same author

    Fatal Outbreak of Botulism among Labrador Eskimos.

    British medical journal·2010
    Same author

    C-reactive protein lowering with rosuvastatin in the METEOR study.

    Journal of internal medicine·2010
    Same author

    Intensive lipid lowering may reduce progression of carotid atherosclerosis within 12 months of treatment: the METEOR study.

    Journal of internal medicine·2009

    Area of Science:

    • Neurology
    • Geriatrics
    • Pharmacology

    Background:

    • Chronic brain failure affects aged populations.
    • Dementia progression is a significant concern in elderly patients.
    • Piracetam is a nootropic agent with potential cognitive-enhancing properties.

    Purpose of the Study:

    • To evaluate the efficacy of piracetam in preventing dementia progression in aged patients.
    • To assess piracetam's impact on cognitive function in individuals with chronic brain failure.

    Main Methods:

    • A double-blind, placebo-controlled trial involving 109 elderly patients.
    • Randomized assignment to piracetam (2.4 g/day) or placebo for 6 weeks.
    • Assessment using 19 psychological tests administered at 6-week intervals.

    Main Results:

    • Piracetam demonstrated statistically significant improvement in only one of 19 psychological tests.
    • Observed improvements with piracetam were limited to the initial 6 weeks of treatment.
    • No significant long-term benefits of piracetam were detected.

    Conclusions:

    • The findings do not support the use of piracetam for treating chronic brain failure or preventing dementia progression.
    • Piracetam's effectiveness in this patient group appears limited and transient.
    • Further research may be needed to explore alternative treatments for cognitive decline in the elderly.

    Related Experiment Videos