90-day sub-chronic inhalation toxicity of a mercapto-functional silicone oil in rats

A mercapto-functional poly(dimethylsiloxane) silicone oil vapor (0.15 and 0.45 mg/l) was generated by passage of air through the heated oil and rats were subjected to these vapors over a 90-day period. An extensive pathological, clinical and hematological workup failed to demonstrate any significant effects of this exposure. In addition, weight gains over the experimental period were comparable to controls.