Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Normal and abnormal intestinal absorption by humans.

W D Heizer

    Environmental Health Perspectives
    |December 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    The intestine has a large reserve capacity for nutrient absorption, but over 30 diseases can cause malabsorption. Stool fat analysis is key for diagnosing malabsorption syndrome.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effect of Ritonavir on (99m)Technetium-Mebrofenin Disposition in Humans: A Semi-PBPK Modeling and In Vitro Approach to Predict Transporter-Mediated DDIs.

    CPT: pharmacometrics & systems pharmacology·2013
    Same author

    In vitro-in vivo correlation of hepatobiliary drug clearance in humans.

    Clinical pharmacology and therapeutics·2007
    Same author

    Comparison of zafirlukast (Accolate) absorption after oral and colonic administration in humans.

    Pharmaceutical research·2000
    Same author

    Use of the InteliSite capsule to study ranitidine absorption from various sites within the human intestinal tract.

    Pharmaceutical research·1999
    Same author

    Acute myeloblastic leukemia following prolonged treatment of Crohn's disease with 6-mercaptopurine.

    Digestive diseases and sciences·1998
    Same author

    Effect of pancreatico-biliary secretions and GI transit time on the absorption and pharmacokinetic profile of ranitidine in humans.

    Pharmaceutical research·1998
    Same journal

    A New Start.

    Environmental health perspectives·2026
    Same journal

    Time-Varying Exposure to Element Mixtures and Children's Cognition at 5 Years of Age: Findings from the New Hampshire Birth Cohort Study.

    Environmental health perspectives·2026
    Same journal

    Effect of Household Air Pollution on the Gut Microbiome and Virome of Adult Women Living in Uganda.

    Environmental health perspectives·2026
    Same journal

    Comparison of Temperature-Mortality Associations across the Middle East Using Different Exposure Estimation Approaches.

    Environmental health perspectives·2026
    Same journal

    Workflow for Statistical Analysis of Environmental Mixtures.

    Environmental health perspectives·2026
    Same journal

    Effects of Extreme Heat Exposure on Heatstroke and Liver Injury in Mice: The Role of PPARα.

    Environmental health perspectives·2026
    See all related articles

    Area of Science:

    • Gastroenterology
    • Human Physiology
    • Nutritional Science

    Background:

    • Adults on a Western diet absorb significant amounts of fat, carbohydrates, and protein daily.
    • Normal digestion and absorption depend on gastric, pancreatic, liver-biliary, mucosal, and lymphatic functions.
    • The intestine possesses substantial reserve capacity for nutrient absorption, often masking defects in common diseases.

    Purpose of the Study:

    • To review the causes and diagnostic approaches for nutrient malabsorption.
    • To categorize diseases leading to malabsorption syndrome.
    • To highlight advancements in malabsorption testing.

    Main Methods:

    • Review of existing literature on nutrient digestion, absorption, and malabsorption.
    • Categorization of malabsorption syndromes based on underlying deficiencies.

    Related Experiment Videos

  • Discussion of diagnostic tests including stool fat analysis and breath tests.
  • Emphasis on per oral biopsy for intestinal epithelial cell function studies.

    • Main Results:

    • Over 30 less common diseases can cause malabsorption of one or more nutrients.
    • Malabsorption syndromes are categorized by deficiencies in pancreatic enzymes, bile acids, or small intestinal wall integrity.
    • Current diagnostic tests are often insensitive; stool fat analysis remains a primary diagnostic tool for malabsorption syndrome.
    • Breath tests and per oral biopsy offer advanced diagnostic capabilities.

    Conclusions:

    • While the intestine has significant absorptive reserves, specific diseases can lead to malabsorption.
    • Accurate diagnosis of malabsorption syndrome relies on identifying the underlying cause, with stool fat analysis being crucial.
    • Emerging diagnostic technologies like breath tests and tissue analysis show promise for improved detection and quantification of malabsorption.