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Regenerative calcium release within muscle cells.

L E Ford, R J Podolsky

    Science (New York, N.Y.)
    |January 2, 1970
    PubMed
    Summary
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    Free calcium ions initiate the release of stored calcium from the sarcoplasmic reticulum in muscle cells. This occurs specifically in skinned skeletal muscle fibers when magnesium ion concentration is low.

    Area of Science:

    • Muscle physiology
    • Cellular calcium signaling

    Background:

    • The sarcoplasmic reticulum stores calcium ions, crucial for muscle contraction.
    • Magnesium ions play a role in regulating calcium release from intracellular stores.

    Purpose of the Study:

    • To investigate the effect of low magnesium ion concentration on calcium release from the sarcoplasmic reticulum.
    • To determine if free calcium can trigger calcium release in skinned skeletal muscle fibers.

    Main Methods:

    • Utilized skinned skeletal muscle fibers.
    • Manipulated extracellular solution composition, specifically lowering magnesium ion concentration.
    • Observed calcium release from the sarcoplasmic reticulum.

    Main Results:

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  • Free calcium was found to trigger the release of stored calcium.
  • This effect was observed in skinned skeletal muscle fibers.
  • The phenomenon was dependent on a low concentration of magnesium ions.

    • Conclusions:

    • Free calcium acts as a trigger for calcium-induced calcium release from the sarcoplasmic reticulum in skeletal muscle.
    • Low magnesium ion environments facilitate this calcium release mechanism.