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Electrophysiological aspects of human sphincter function.

T J Ustach, F Tobon, T Hambrecht

    The Journal of Clinical Investigation
    |January 1, 1970
    PubMed
    Summary
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    The internal anal sphincter exhibits a unique electrical rhythm (BER) that maintains muscle tone. This basic electrical rhythm is inhibited during reflex relaxation, suggesting active control of sphincter function.

    Area of Science:

    • Gastroenterology
    • Physiology
    • Electrophysiology

    Background:

    • The internal anal sphincter's electrophysiology and function are not fully understood.
    • Existing concepts of sphincter function require further investigation.

    Purpose of the Study:

    • To investigate the electrophysiology of the human internal anal sphincter.
    • To explore the relationship between electrical activity and sphincter function.

    Main Methods:

    • Simultaneous manometric and electrical recordings were performed on the internal anal sphincter.
    • Studies included normal subjects, patients with functional bowel disease, and patients with spinal cord lesions.

    Main Results:

    • A basic electrical rhythm (BER) was recorded in all subjects, originating in the internal anal sphincter.

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  • BER frequency was higher than in other gastrointestinal muscles and correlated with resting pressure.
  • Rectal distension induced sphincter relaxation by inhibiting BER, proportional to stimulus strength.

    • Conclusions:

    • The internal anal sphincter possesses a unique, high-frequency BER originating intrinsically.
    • Sphincter tone maintenance is an active process regulated by BER.
    • BER inhibition correlates with reflex sphincter relaxation, indicating its role in modulating sphincter function.