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Related Experiment Videos

Silicon: a possible factor in bone calcification.

E M Carlisle

    Science (New York, N.Y.)
    |January 16, 1970
    PubMed
    Summary
    This summary is machine-generated.

    Silicon is a trace element found in active bone calcification sites. It is associated with calcium during early bone formation, decreasing as bone matures.

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    Biochemical and morphological changes associated with long bone abnormalities in silicon deficiency.

    The Journal of nutrition·1980

    Area of Science:

    • Biochemistry
    • Orthopedics
    • Nutritional Science

    Background:

    • Silicon is an understudied trace element in nutrition.
    • Bone calcification is a complex biomineralization process.

    Purpose of the Study:

    • To investigate the localization and role of silicon in bone calcification.
    • To determine the relationship between silicon and calcium during bone formation.

    Main Methods:

    • Localization of silicon in active calcification sites in young bone.
    • Analysis of silicon and calcium concentrations at different stages of calcification.

    Main Results:

    • Silicon was uniquely localized in active calcification sites.
    • Silicon concentration increased with calcium at low calcium levels.

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  • Silicon levels decreased below detection limits as bone approached hydroxyapatite composition.

    • Conclusions:

    • Silicon is associated with calcium in the early stages of bone calcification.
    • Silicon may play a role in the initial phases of bone mineralization.