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Hemodynamic responses to DOCA in young pigs.
Hypertension (Dallas, Tex. : 1979)
|November 1, 1979
Summary
Mineralocorticoid hypertension, induced by desoxycorticosterone acetate (DOCA), elevates mean arterial pressure (MAP) by increasing cardiac output or total peripheral resistance. This study suggests arterial pressure itself is the regulated variable in this hypertension model.
Area of Science:
- Cardiovascular Physiology
- Endocrinology
- Hypertension Research
Background:
- Mineralocorticoids, like desoxycorticosterone acetate (DOCA), are known to influence blood pressure.
- Understanding the mechanisms of DOCA-induced hypertension is crucial for managing cardiovascular diseases.
Purpose of the Study:
- To investigate the hemodynamic changes associated with desoxycorticosterone acetate (DOCA)-induced hypertension in young pigs.
- To determine whether arterial pressure, cardiac output, or total peripheral resistance is the primary regulated variable.
Main Methods:
- Hemodynamic variables were measured in 20 young pigs.
- Thirteen pigs received subcutaneous desoxycorticosterone acetate (DOCA) implants; seven served as controls.
- Mean arterial pressure (MAP), cardiac output (CO), and total peripheral resistance (TPR) were monitored over two weeks.
Main Results:
- DOCA-treated pigs showed a significant increase in MAP compared to controls, plateauing at 38% above baseline.
- MAP elevation was driven by either increased cardiac output (CO) or increased total peripheral resistance (TPR) in different individuals.
- Increased central venous pressure was observed in many DOCA-treated pigs, irrespective of the mechanism of MAP elevation.
Conclusions:
- Arterial pressure appears to be the regulated variable in this model of mineralocorticoid hypertension.
- The underlying regulatory system, potentially in the kidney or central nervous system, adjusts CO or TPR to maintain elevated arterial pressure.