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Staphcoccomycin, a new basic macrolide antibiotic.

I R Shimi, S Shoukry, F T Ali

    The Journal of Antibiotics
    |December 1, 1979
    PubMed
    Summary
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    A new basic macrolide antibiotic, Staphcoccomycin (SCM), was discovered from Streptomyces. Its structure was identified as a des-mycarosyl derivative of angolamycin, confirmed by mass spectrometry and NMR.

    Area of Science:

    • Microbiology
    • Natural Product Chemistry
    • Pharmacology

    Background:

    • Basic macrolide antibiotics are crucial in combating bacterial infections.
    • Streptomyces species are a prolific source of novel bioactive compounds.
    • The discovery of new antibiotics is vital due to rising antimicrobial resistance.

    Purpose of the Study:

    • To isolate and characterize a novel macrolide antibiotic from Streptomyces sp. AS-NG 16.
    • To elucidate the chemical structure of the newly discovered compound, Staphcoccomycin (SCM).
    • To compare SCM with known macrolides to determine its structural relationship.

    Main Methods:

    • Isolation of SCM from Streptomyces sp. AS-NG 16 fermentation broth.
    • Purification and determination of physical and chemical properties.

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  • Mass spectrometry (MS) and Nuclear Magnetic Resonance (NMR) spectroscopy for structural elucidation.

    • Main Results:

    • Staphcoccomycin (SCM) was successfully produced and purified.
    • MS analysis indicated SCM is a des-mycarosyl derivative of angolamycin.
    • 1H-NMR data and molecular ion peak (m/e 771, C39H65NO14) confirmed the proposed structure.

    Conclusions:

    • Staphcoccomycin (SCM) represents a novel basic macrolide antibiotic.
    • SCM's structure is closely related to angolamycin.
    • Further research into SCM's biological activity and potential therapeutic applications is warranted.