Related Experiment Video

Updated: Aug 7, 2026

Intranasal Administration of Recombinant Influenza Vaccines in Chimeric Mouse Models to Study Mucosal Immunity
10:39

Intranasal Administration of Recombinant Influenza Vaccines in Chimeric Mouse Models to Study Mucosal Immunity

Published on: June 25, 2015

Vaccination of school children with live mumps virus vaccine

J Furesz, F P Nagler

    Canadian Medical Association Journal
    |May 30, 1970
    PubMed

    Insights

    The live, attenuated mumps virus vaccine (Mumpsvax) demonstrated excellent safety and efficacy in school children. Antibody responses were observed in most susceptible children, confirming vaccine effectiveness.

    Area of Science:

    • Pediatrics
    • Immunology
    • Vaccinology

    Background:

    • Mumps virus vaccine (Mumpsvax) is a live, attenuated vaccine.
    • Assessing vaccine safety and immunogenicity in children is crucial.

    Purpose of the Study:

    • To evaluate the safety and efficacy of the live, attenuated mumps virus vaccine in school-aged children.
    • To assess the serological response to mumps vaccination in both susceptible and previously exposed children.

    Main Methods:

    • Administered live, attenuated mumps virus vaccine (Mumpsvax) to 146 school children aged 6-9 years.
    • Monitored for clinical reactions post-vaccination.
    • Conducted serological testing to measure neutralizing antibody titers before and after vaccination.

    Main Results:

    • No significant clinical reactions were observed, except for one suspected pre-vaccination infection.
    • 93.5% of initially susceptible children developed specific antibodies to mumps virus 28 days post-vaccination.
    • 26.2% of initially seropositive children showed a significant antibody response, influenced by pre-existing antibody levels.

    Conclusions:

    • The live, attenuated mumps virus vaccine (Mumpsvax) is safe for use in children aged 6-9 years.
    • The vaccine effectively induces an antibody response in susceptible children, indicating efficacy.
    • Pre-existing antibody levels can influence the response to the mumps vaccine.

    More Related Videos

    Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice08:52

    Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

    Published on: February 22, 2019

    Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique09:37

    Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique

    Published on: September 23, 2022

    Related Concept Videos

    Vaccinations01:51

    Vaccinations

    Overview
    Vaccines01:21

    Vaccines

    Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...
    Smallpox01:24

    Smallpox

    Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.
    Chickenpox01:20

    Chickenpox

    Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...
    Poliomyelitis01:17

    Poliomyelitis

    Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
    Respiratory Syncytial Virus Disease01:29

    Respiratory Syncytial Virus Disease

    Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...