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Hypoxic ventilatory drive in normal man.

J V Weil, E Byrne-Quinn, I E Sodal

    The Journal of Clinical Investigation
    |June 1, 1970
    PubMed
    Summary
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    This study introduces a new method to measure the human ventilatory response to hypoxia, revealing a hyperbolic relationship between oxygen levels and breathing. This technique quantifies hypoxic ventilatory drive and its interaction with carbon dioxide levels.

    Area of Science:

    • Respiratory Physiology
    • Cardiopulmonary Regulation
    • Hypoxia Response

    Background:

    • The ventilatory response to hypoxia is crucial for maintaining oxygen homeostasis.
    • Quantifying the hypoxic ventilatory drive and its interaction with hypercapnia is essential for understanding respiratory control.

    Purpose of the Study:

    • To describe a novel technique for continuously measuring the ventilatory response to isocapnic hypoxia in humans.
    • To characterize the relationship between alveolar oxygen tension and minute ventilation.
    • To evaluate the influence of carbon dioxide levels on the hypoxic ventilatory response.

    Main Methods:

    • A non-steady-state method was employed to record the ventilatory response to isocapnic hypoxia.
    • Minute ventilation and alveolar oxygen tension (PaO2) were continuously monitored.

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  • Alveolar carbon dioxide tension (PaCO2) was kept constant by adjusting inspired gas composition.
  • Data were fitted to a hyperbolic function to quantify the hypoxic drive (parameter A).

    • Main Results:

    • The ventilatory response to decreasing PaO2 followed a hyperbolic curve, with a steep increase in ventilation below 50-60 mm Hg.
    • The parameter A, representing hypoxic drive, was reproducible within subjects and similar across subjects.
    • Elevated PaCO2 significantly increased parameter A, while decreased PaCO2 lowered it, demonstrating interaction between stimuli.
    • Ventilation showed a linear relationship with arterial oxygen content, suggesting chemoreceptor tissue oxygen tension is a key factor.

    Conclusions:

    • The developed technique provides a reliable method for assessing hypoxic ventilatory drive.
    • The interaction between hypercapnia and hypoxia significantly modulates the ventilatory response.
    • Arterial oxygen content, influenced by circulatory oxygen delivery, appears to be a critical determinant of the ventilatory response to hypoxia.