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Haloprogin: a topical antifungal agent

E F Harrison, P Zwadyk, R J Bequette

    Applied Microbiology
    |May 1, 1970
    PubMed

    Insights

    Haloprogin effectively treats topical fungal infections in guinea pigs, showing broad-spectrum activity against yeasts and bacteria. It demonstrates comparable antifungal efficacy to tolnaftate but with added antimonilial and antibacterial benefits.

    Area of Science:

    • Mycology
    • Dermatology
    • Antimicrobial research

    Background:

    • Topical mycotic infections require effective antifungal agents.
    • Haloprogin and tolnaftate are topical antifungal agents with distinct activity profiles.

    Purpose of the Study:

    • To evaluate the efficacy of haloprogin against experimentally induced topical mycotic infections.
    • To compare the in vitro and in vivo activity spectrum of haloprogin with tolnaftate.

    Main Methods:

    • Experimental induction of topical mycotic infections in guinea pigs.
    • In vitro susceptibility testing against yeasts, Candida species, gram-positive bacteria, and dermatophytes.
    • Comparative efficacy assessment with tolnaftate in vivo and in vitro.

    Main Results:

    • Haloprogin demonstrated high efficacy in treating topical mycotic infections in guinea pigs.
    • In vitro, haloprogin was active against yeasts, Candida, and gram-positive bacteria, with antifungal activity comparable to tolnaftate against dermatophytes.
    • Haloprogin exhibited significant antimonilial and selective antibacterial activity, unlike tolnaftate.
    • Serum reduced haloprogin's in vitro antifungal activity more than tolnaftate's, but topical application showed no diminished efficacy.

    Conclusions:

    • Haloprogin possesses a broad spectrum of antimicrobial activity, including antifungal, antimonilial, and antibacterial properties.
    • Its efficacy against dermatophytes in vivo was not diminished by serum, suggesting clinical potential.
    • Haloprogin may be a superior topical agent for treating human dermatophytic and monilial infections.

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