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Related Experiment Videos

Chromosomal aberrations induced in barley by LSD.

M P Singh, C S Kalia, H K Jain

    Science (New York, N.Y.)
    |July 31, 1970
    PubMed
    Summary

    Lysergic acid diethylamide (LSD) treatment caused significant chromosomal aberrations, primarily chromosome breaks, in hulled barley (Hordeum vulgare) root tips. Many of these breaks occurred near the primary constriction, indicating a specific sensitivity in this region.

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    Area of Science:

    • Plant genetics
    • Cytology
    • Genotoxicology

    Background:

    • Hulled barley (Hordeum vulgare) is a globally important cereal crop.
    • Chromosomal aberrations can impact plant growth and development.
    • Understanding the genotoxic effects of chemical agents is crucial for agricultural and environmental safety.

    Purpose of the Study:

    • To investigate the cytogenetic effects of lysergic acid diethylamide (LSD) on hulled barley.
    • To identify the types and distribution of chromosomal damage induced by LSD.

    Main Methods:

    • Seed germination of hulled barley (Hordeum vulgare).
    • Treatment of germinated seeds with lysergic acid diethylamide (LSD).
    • Feulgen staining of squashed root tip preparations.
    • Microscopic analysis for chromosomal aberrations.

    Main Results:

    • Extensive chromosomal aberrations were observed in barley root tips following LSD treatment.
    • Chromosome breaks were the predominant type of aberration.
    • Approximately 50% of the observed chromosome breaks occurred in the primary constriction region.

    Conclusions:

    • Lysergic acid diethylamide (LSD) induces significant genotoxicity in hulled barley.
    • The primary constriction is a sensitive site for LSD-induced chromosome breakage in Hordeum vulgare.
    • These findings highlight the potential of LSD to disrupt plant chromosomal integrity.

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