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Synthesis of tritium-labeled N-acetyl PGE2 carboxamide (CP-27,987)
Prostaglandins
|November 1, 1979
Abstract:
The preparation of N-acetyl PGE2 carboxamide (CP-27,987) regioselectively labeled at C-18 and C-19 with tritium is described. The overall radiochemical yield was 8.0% at a specific activity of 0.49 Ci/mmole. The synthesis employed is applicable to the preparation of tritium labeled natural prostaglandins and a variety of analogs.