Human erythropoiesis in diffusion chambers

The diffusion chamber technique has been modified in order to stimulate human erythropoiesis in addition to granulo- and monocytopoiesis. The chamber recipient mice were subjected to a combination of 750 rad irradiation and long-term non-interrupted hypoxia (0.5 atm) without chamber retransplantation. 7 d after implantation erythroid cells started to increase, reaching a maximum of up to 70% of the nucleated cells on day 12.