Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in platelet aggregability after ovariectomy.

H Yamazaki, T Motomiya, M Sonoda

    Thrombosis and Haemostasis
    |December 21, 1979
    PubMed
    Summary

    Ovarian hormones, particularly estrogen, appear to enhance platelet activation, specifically secondary aggregation. This effect was observed to diminish after hysterectomy with ovariectomy, suggesting a hormonal influence on platelet function.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Analysis of an initial step of T cell adhesion to endothelial monolayers under flow conditions.

    Journal of immunology (Baltimore, Md. : 1950)·1995
    Same author

    Involvement of alpha v beta 3 integrin in mediating fibrin gel retraction.

    The Journal of biological chemistry·1995
    Same author

    KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria.

    Cell·1994
    Same author

    Interleukin 6 receptor mRNA in prostate carcinomas and benign prostate hyperplasia.

    The Journal of urology·1994
    Same author

    Metabolism of FK506, a potent immunosuppressive agent, by cytochrome P450 3A enzymes in rat, dog and human liver microsomes.

    Biochemical pharmacology·1994
    Same author

    Platelet glycoprotein IV (CD36) deficiency is associated with the absence (type I) or the presence (type II) of glycoprotein IV on monocytes.

    Blood·1994

    Area of Science:

    • Gynecology
    • Hematology
    • Endocrinology

    Background:

    • Uterine myomas are common gynecological conditions.
    • Platelet activation plays a role in hemostasis and thrombosis.
    • The influence of ovarian hormones on platelet function is not fully understood.

    Purpose of the Study:

    • To investigate the impact of hysterectomy with and without ovariectomy on platelet aggregation in patients with uterine myomas.
    • To explore the role of ovarian hormones in platelet activation.

    Main Methods:

    • Prospective study of 48 patients with uterine myomas undergoing hysterectomy.
    • Patients divided into ovariectomized (n=25) and control (n=23) groups.
    • Platelet count and aggregation (primary, secondary, collagen-induced) assessed pre- and post-operatively.

    Related Experiment Videos

    Main Results:

    • Platelet count and secondary aggregation initially decreased then increased post-surgery in both groups.
    • A significant decrease in ADP-induced secondary aggregation was noted one month post-operation.
    • The enhancement of 5-min aggregation persisted in the control group but ceased in the ovariectomized group, indicating a hormonal effect.

    Conclusions:

    • Ovarian hormones, primarily estrogen, likely facilitate platelet activation via secondary aggregation.
    • Hysterectomy with ovariectomy reduces this hormone-mediated platelet activation.
    • Findings suggest a link between hormonal status and platelet responsiveness.