Related Experiment Video

Updated: Aug 17, 2026

Assessment of Calcium Sparks in Intact Skeletal Muscle Fibers
11:22

Assessment of Calcium Sparks in Intact Skeletal Muscle Fibers

Published on: February 24, 2014

Calcium uptake and bioelectrical activity of denervated and myotonic muscle

H Radu, I Gödri, E Albu

    Journal of Neurology, Neurosurgery, and Psychiatry
    |June 1, 1970
    PubMed

    More Related Videos

    Assessment of Myofilament Ca2+ Sensitivity Underlying Cardiac Excitation-contraction Coupling08:29

    Assessment of Myofilament Ca2+ Sensitivity Underlying Cardiac Excitation-contraction Coupling

    Published on: August 1, 2016

    Ex Vivo Imaging of Cell-specific Calcium Signaling at the Tripartite Synapse of the Mouse Diaphragm08:42

    Ex Vivo Imaging of Cell-specific Calcium Signaling at the Tripartite Synapse of the Mouse Diaphragm

    Published on: October 4, 2018

    Related Concept Videos

    Muscle Contraction01:15

    Muscle Contraction

    Cross-bridge Cycle01:26

    Cross-bridge Cycle

    As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.
    Muscle Contraction01:10

    Muscle Contraction

    In skeletal muscles, acetylcholine is released by nerve terminals at the motor endplate—the point of synaptic communication between motor neurons and muscle fibers. The binding of acetylcholine to its receptors on the sarcolemma allows entry of sodium ions into the cell and triggers an action potential in the muscle cell. Thus, electrical signals from the brain are transmitted to the muscle. Subsequently, the enzyme acetylcholinesterase breaks down acetylcholine to prevent excessive muscle...
    Generation of Action Potential in Skeletal Muscles01:24

    Generation of Action Potential in Skeletal Muscles

    Every cell in the body maintains a membrane potential due to an uneven distribution of positive and negative charges across its plasma membrane. The membrane potential is measured in millivolts and quantifies the difference in charge across the membrane.
    Like neurons, muscle cells are also regarded as excitable due to their capacity to change in response to stimuli, primarily due to voltage-gated ion channels embedded in their plasma membranes, which get activated by alterations in the cell's...
    Relaxation of Skeletal Muscles01:29

    Relaxation of Skeletal Muscles

    The period of muscle contraction primarily influences the duration of stimulation at the neuromuscular junction (NMJ), the presence of free calcium ions in the sarcoplasm, and the availability of energy or ATP to support contractions.
    When an action potential reaches the axon terminal, it depolarizes the membrane and opens voltage-gated sodium channels. Sodium ions enter the cell, further depolarizing the presynaptic membrane. This depolarization causes voltage-gated calcium channels to open.