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Updated: Aug 10, 2026
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Published on: December 26, 2017
[Bone marrow depression with peripheral pancytopenia under the treatment with an ampicillin/oxacillin combination
Abstract:
Under the treatment with ampicillin or oxacillin resp. hematologic changes turn up very rarely except for eosinophilia, in addition it is only granulocytes or platelets alone which are involved in the cases yet published. In the case presented here therapy by an ampicillin/Oxacillin combination induces bone marrow depression with peripheral pancytopenia on a toxic or allergic base.
Insights
Ampicillin and oxacillin rarely cause hematologic issues, usually affecting only granulocytes or platelets. However, this case shows their combination can lead to severe bone marrow depression and pancytopenia.
Area of Science:
- Hematology
- Pharmacology
- Toxicology
Background:
- Ampicillin and oxacillin are commonly used antibiotics.
- Previous reports indicate rare hematologic side effects, primarily eosinophilia, granulocytopenia, or thrombocytopenia.
