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Cortisone mediated decrease in fetal metabolism of glucose.

W J Waddell, C Marlowe

    Archives Internationales De Pharmacodynamie Et De Therapie
    |November 1, 1979
    PubMed
    Summary

    Cortisone administration reduced glucose transfer to the fetus in pregnant mice. This suggests cortisone

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    Area of Science:

    • Biochemistry
    • Developmental Biology
    • Pharmacology

    Background:

    • Cortisone is a known teratogen.
    • Maternal metabolism significantly impacts fetal development.

    Purpose of the Study:

    • To investigate the effect of cortisone on glucose transfer to the fetus.
    • To elucidate the mechanism of cortisone-induced teratogenesis.

    Main Methods:

    • Administered 14C-glucose to pregnant mice.
    • Treated mice with and without a teratogenic dose of cortisone.
    • Measured distribution of glucose and metabolites in maternal and fetal tissues.

    Main Results:

    • Cortisone decreased fetal and placental glucose transfer.
    • Cortisone increased glucose disposition in maternal liver and muscle.
    • Observed a shift in carbohydrate metabolism away from the fetus.

    Conclusions:

    • Cortisone teratogenicity may result from fetal carbohydrate deprivation.
    • Maternal metabolic changes induced by cortisone impact fetal development.
    • Adequate carbohydrate supply is crucial during critical fetal growth periods.

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