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Urinary hydroxyproline in the elderly with low leucocyte ascorbic acid levels.

A C Windsor, C B Williams

    British Medical Journal
    |March 21, 1970
    PubMed
    Summary
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    Elderly individuals with low ascorbic acid (vitamin C) levels showed improved collagen metabolism markers during vitamin C supplementation. This suggests vitamin C supplements may benefit older adults with impaired collagen synthesis.

    Area of Science:

    • Biochemistry
    • Gerontology
    • Nutritional Science

    Background:

    • Collagen metabolism is crucial for maintaining tissue integrity, particularly in aging populations.
    • Ascorbic acid (vitamin C) is an essential cofactor in collagen synthesis.
    • Impaired collagen metabolism may be linked to suboptimal vitamin C levels in the elderly.

    Purpose of the Study:

    • To investigate the effect of ascorbic acid supplementation on collagen metabolism in elderly patients.
    • To determine if baseline ascorbic acid levels influence the response to vitamin C treatment.

    Main Methods:

    • Fourteen elderly patients (aged 58-91) with varied leucocyte ascorbic acid levels were enrolled.
    • Urinary hydroxyproline/creatinine ratios were measured before, during, and after a 6-day treatment with 1g ascorbic acid daily.

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  • Leucocyte ascorbic acid levels were assessed to categorize patients based on vitamin C status.

    • Main Results:

    • A significant increase in the urinary hydroxyproline/creatinine ratio was observed during ascorbic acid treatment.
    • This improvement was most pronounced in patients with initial leucocyte ascorbic acid levels below 15 µg/10^8 white blood cells.
    • The findings suggest a direct impact of vitamin C on collagen turnover markers.

    Conclusions:

    • Collagen metabolism may be impaired in elderly individuals with low ascorbic acid levels.
    • Ascorbic acid supplementation (1g daily) positively influences collagen metabolism markers in this population.
    • Routine ascorbic acid supplementation is recommended for elderly patients exhibiting low vitamin C levels.