Related Experiment Video

Updated: Aug 18, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Malaria resistance: artificial induction with a partially purified plasmodial fraction

L E D'Antonio, D T Spira, R C Fu

    Science (New York, N.Y.)
    |May 29, 1970
    PubMed

    Insights

    Researchers developed a Plasmodium berghei vaccine from mouse red blood cells. This erythrocyte-free fraction protected mice against malaria infection, preventing disease and death.

    Area of Science:

    • Malariology
    • Immunology
    • Parasitology

    Background:

    • Malaria remains a significant global health challenge.
    • Effective vaccines are crucial for malaria control and eradication efforts.

    Purpose of the Study:

    • To isolate and characterize a Plasmodium berghei fraction with potential vaccine properties.
    • To evaluate the efficacy of this fraction in preventing malaria in a mouse model.

    Main Methods:

    • Plasmodium berghei were isolated from mouse erythrocytes using a French pressure cell.
    • Isolated organisms were washed, disintegrated, and fractionated via Sephadex (G-200) chromatography.
    • The void-volume eluate, an erythrocyte-free fraction, was collected for further analysis.

    Main Results:

    • An erythrocyte-free Plasmodium berghei fraction was successfully isolated.
    • This fraction demonstrated significant vaccine-like activity in mice.
    • Protected mice showed no parasitemia, anemia, or mortality upon challenge with live Plasmodium berghei.

    Conclusions:

    • An erythrocyte-free fraction of Plasmodium berghei possesses potent malaria vaccine potential.
    • This finding opens avenues for developing novel malaria vaccines.
    • Further research is warranted to explore the immunogenic components and mechanisms of this protective fraction.

    More Related Videos

    Detection and Isolation of Apoptotic Bodies to High Purity12:17

    Detection and Isolation of Apoptotic Bodies to High Purity

    Published on: August 12, 2018

    Generating Controlled, Dynamic Chemical Landscapes to Study Microbial Behavior10:07

    Generating Controlled, Dynamic Chemical Landscapes to Study Microbial Behavior

    Published on: January 31, 2020

    Related Concept Videos

    Microbial Bioremediation of Pesticides01:28

    Microbial Bioremediation of Pesticides

    Pesticides often feature structurally complex chemical architectures, incorporating halogen groups and multiple aromatic rings. These characteristics confer high chemical stability, rendering many pesticides resistant to natural degradation processes. This resistance poses significant environmental concerns, as persistent pesticide residues can accumulate in ecosystems and affect non-target organisms.Despite the inherent stability of many pesticides, certain microorganisms possess the metabolic...