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Related Experiment Videos

Changes in the molecular composition of circulating hydroxyethyl starch.

S P Farrow, M Hall, C R Ricketts

    British Journal of Pharmacology
    |April 1, 1970
    PubMed
    Summary

    Hydroxyethyl starch (HES) persists longer in circulation than dextrans after intravenous injection. Amylase breaks down HES, reducing its molecular size in vivo.

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    Area of Science:

    • Biochemistry
    • Pharmacology
    • Biomaterials

    Background:

    • Hydroxyethyl starch (HES) is used as a plasma volume expander and cryoprotective agent.
    • Understanding HES behavior in vivo is crucial due to intravenous administration.

    Purpose of the Study:

    • To investigate the in vivo behavior of Hydroxyethyl starch (HES) after intravenous injection in rabbits.
    • To compare the persistence of HES with clinical dextrans in circulation.

    Main Methods:

    • Intravenous injection of HES and dextrans into rabbits.
    • Plasma level determination using the anthrone method.
    • Gel filtration analysis of recovered HES to assess molecular size distribution.
    • In vitro assessment of amylase activity on HES.

    Main Results:

    • HES demonstrated longer persistence in rabbit circulation compared to dextrans.
    • Recovered HES exhibited a narrower molecular size distribution, indicating removal of smaller and larger molecules.
    • Amylase was shown to degrade HES into intermediate-sized molecules with minimal maltose production.

    Conclusions:

    • HES exhibits prolonged circulation time compared to dextrans.
    • Renal filtration and reticuloendothelial system activity likely contribute to HES clearance.
    • Endogenous or exogenous amylase may play a role in HES metabolism.

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