Determination of the concentration of plasma proteins by density measurement

Density measurement with a commercially available instrument (DMA 46, PAAR) was studied as an alternative method to the time-consuming and sometimes expensive methods currently in use for the determination of protein concentrations. The method is very useful for protein estimation in salt--and alcohol--free albumin bulk solutions and as an additional end product test for albumin and immunoglobulin solutions; it may also be used in the determination of total protein in plasma.