Related Experiment Videos
Purity, anticomplementary activity, and viral antibody profile of NIG preparations for intravenous and intramuscular
16 normal immunoglobulin preparations of 4 different manufacturers for intravenous and intramuscular use were tested with regard to purity, anticomplementary activity, and viral antibody profile. Besides IgG, which accounted for the main part of the protein content, small amounts of IgA, IgD, and IgM were found. IgE was detected in every batch studied. Some contained IgE-concentrations, which are usually seen in atopic persons. Anticomplementary activity was detected in preparations for i.m. application but surprisingly also in some preparations for intravenous use, a fact which may possibly cause allergic or anaphylactic reactions. The investigated batches showed almost the same variety of viral antibodies and only slightly differing antibody titers. Antibodies to vaccinia virus could not be demonstrated.
16 normal immunoglobulin preparations of 4 different manufacturers for intravenous and intramuscular use were tested with regard to purity, anticomplementary activity, and viral antibody profile. Besides IgG, which accounted for the main part of the protein content, small amounts of IgA, IgD, and IgM were found. IgE was detected in every batch studied. Some contained IgE-concentrations, which are usually seen in atopic persons. Anticomplementary activity was detected in preparations for i.m. application but surprisingly also in some preparations for intravenous use, a fact which may possibly cause allergic or anaphylactic reactions. The investigated batches showed almost the same variety of viral antibodies and only slightly differing antibody titers. Antibodies to vaccinia virus could not be demonstrated.