Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bactericidal substance from Staphylococcus aureus. Biological properties.

A S Dajani, E D Gray, L W Wannamaker

    The Journal of Experimental Medicine
    |May 1, 1970
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The Epidemiology and Prevention of Rheumatic Fever.

    Bulletin of the New York Academy of Medicine·2009
    Same author

    Beta-lactam resistance: clinical implications for pediatric patients.

    The Journal of international medical research·2002
    Same author

    Optimisation of the prevention and treatment of bacterial endocarditis.

    Drugs & aging·2001
    Same author

    Further observations and characterization of monoclonal antibodies reacting with B cell alloantigens associated with rheumatic fever and rheumatic heart disease.

    The Journal of laboratory and clinical medicine·2000
    Same author

    Moraxella catarrhalis bacteremia: a 10-year experience.

    Southern medical journal·1999
    Same author

    Prevalence of penicillin-resistant viridans streptococci in the oral flora of Japanese children at risk for infective endocarditis.

    Circulation·1999
    Same journal

    Retraction: In vivo NCL targeting affects breast cancer aggressiveness through miRNA regulation.

    The Journal of experimental medicine·2026
    Same journal

    Intravesical mesothelin-based CAR T cells targeting MUC16 effectively control bladder cancer in preclinical models.

    The Journal of experimental medicine·2026
    Same journal

    Flawed translation triggers oncogenic B-T cell communication.

    The Journal of experimental medicine·2026
    Same journal

    Correction: LCK'ed in: Inborn errors of immunity in LCK reveal how TCR signaling is calibrated.

    The Journal of experimental medicine·2026
    Same journal

    Mechanobiology of inflammation: Pulling the strings of innate immunity.

    The Journal of experimental medicine·2026
    Same journal

    Bile acid retention in efferocytic macrophages shapes their inflammatory status during cholangitis.

    The Journal of experimental medicine·2026
    See all related articles

    Researchers identified a new bactericidal substance from Staphylococcus aureus (S. aureus). This unique compound, distinct from bacteriocins, is produced by specific S. aureus strains, offering potential for novel antimicrobial strategies.

    Area of Science:

    • Microbiology
    • Bacteriology
    • Biochemistry

    Background:

    • Staphylococcus aureus (S. aureus) is a significant human pathogen.
    • Bacteriocin-like substances are known antimicrobial agents produced by bacteria.
    • Specific phage types of S. aureus may possess unique properties.

    Purpose of the Study:

    • To further identify and characterize a previously isolated bactericidal substance from S. aureus.
    • To determine the production levels of this substance by different S. aureus phage types.
    • To compare the properties of the substance with known bacteriocins and other S. aureus products.

    Main Methods:

    • Isolation and purification of the bactericidal substance using ammonium sulfate fractionation.
    • Further purification employing gel filtration chromatography on a Sephadex G-100 column.

    Related Experiment Videos

  • Characterization of the substance's properties and comparison with bacteriocins.

    • Main Results:

    • The bactericidal substance is produced in higher titers by Staphylococcus aureus of phage type 71.
    • Strains other than phage type 71 did not produce this specific bactericidal substance.
    • The purified substance exhibits properties similar to bacteriocins but with distinct differences, indicating it is a novel product.

    Conclusions:

    • A novel bactericidal substance produced by Staphylococcus aureus (phage type 71) has been identified and characterized.
    • This substance is a previously unrecognized extracellular product of S. aureus, distinct from known bacteriocins and other secreted proteins.
    • The findings suggest a unique antimicrobial capability within specific S. aureus strains.