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Related Experiment Videos

Histocompatibility-2 (H-2) polymorphism in wild mice.

J Klein

    Science (New York, N.Y.)
    |June 12, 1970
    PubMed
    Summary

    Wild mice in Ann Arbor exhibit unique H-2 antigen phenotypes, differing from lab mice. This suggests distinct genetic structures within natural mouse populations, supporting the concept of deme structure.

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    Area of Science:

    • Immunogenetics
    • Population Genetics
    • Mammalian Genetics

    Background:

    • The H-2 complex in mice is a critical region of the major histocompatibility complex, analogous to the human HLA system.
    • Understanding H-2 antigen diversity in wild populations is essential for population genetics studies and conservation efforts.

    Purpose of the Study:

    • To investigate the H-2 antigen diversity in wild mouse populations from the Ann Arbor area.
    • To compare the H-2 phenotypes of wild mice with those of laboratory mouse strains.
    • To assess the population structure of wild mice based on H-2 antigen profiles.

    Main Methods:

    • Direct hemagglutination tests were performed on red blood cells from 40 wild mice.
    • Mice were captured from four distinct locations within the Ann Arbor region.
    • Phenotyping focused on the presence or absence of 15 different H-2 antigens.

    Main Results:

    • Fifteen unique H-2 antigen phenotypes were identified among the wild mice.
    • All observed phenotypes differed from those associated with known H-2 alleles in laboratory mice.
    • Significant similarity in H-2 phenotypes was noted among mice from the same geographic location.

    Conclusions:

    • The H-2 antigen profiles of wild mice in Ann Arbor are distinct from laboratory strains.
    • The observed genetic similarity within local populations provides evidence for a deme structure in natural mouse populations.
    • This study highlights the genetic differentiation occurring at a local scale in wild rodent populations.

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