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Related Experiment Videos

Saccharomyces cerevisiae: a diffusible sex factor.

W Duntze, V MacKay, T R Manney

    Science (New York, N.Y.)
    |June 19, 1970
    PubMed
    Summary

    Alpha mating-type yeast cells secrete a hormone-like substance that triggers mating in opposite cells. This substance, an oligopeptide, shares genetic factors with yeast mating ability.

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    Area of Science:

    • * Cellular and Molecular Biology
    • * Yeast Genetics and Reproduction

    Background:

    • * Heterothallic yeast strains exhibit distinct mating types (alpha and a).
    • * Cell-to-cell communication is crucial for initiating the mating process in yeast.

    Purpose of the Study:

    • * To investigate the nature of the substance secreted by alpha mating-type yeast cells.
    • * To understand its role in inducing mating behavior in a mating-type cells.
    • * To explore the genetic basis of its secretion and its relationship to mating ability.

    Main Methods:

    • * Partial purification of the secreted hormone-like substance.
    • * Observation of morphological changes in yeast cells upon exposure to the substance.
    • * Analysis of genetic determinants common to substance secretion and mating.

    Main Results:

    • * Alpha mating-type cells secrete a substance that induces characteristic mating morphology in a mating-type cells.
    • * The secreted substance exhibits properties consistent with an oligopeptide.
    • * Common genetic factors influence both the secretion of this substance and the yeast's mating capability.

    Conclusions:

    • * A secreted oligopeptide acts as a signaling molecule in yeast mating.
    • * The genetic control of this signaling pathway is linked to mating ability.
    • * This finding provides insight into the molecular mechanisms of yeast sexual reproduction.

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