Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hemoglobin interaction: modification of solid phase composition in the sickling phenomenon.

J F Bertles, R Rabinowitz, J Döbler

    Science (New York, N.Y.)
    |July 24, 1970
    PubMed
    Summary

    Hemoglobins A and C can form structures during sickle-cell disease, unlike fetal hemoglobin. This finding clarifies the molecular basis of the sickling phenomenon.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Atmospheric Carbon and Transport - America (ACT-America) Data Sets: Description, Management, and Delivery.

    Earth and space science (Hoboken, N.J.)·2021
    Same author

    Prenatal diagnosis of biliary atresia: A case series.

    Early human development·2017
    Same author

    Expression of CD11a (LFA-1) on B-chronic Lymphocytic Leukemia and Lymphoma Cells: Correlation with Cell Surface Immunoglobulin Intensity and CD58 (LFA-3) Expression.

    Leukemia & lymphoma·2016
    Same author

    An 11,000-isolate same plate/same day comparison of the 3 most widely used platforms for analyzing multidrug-resistant clinical pathogens.

    Diagnostic microbiology and infectious disease·2015
    Same author

    Early second trimester transvaginal ultrasound anomaly scan does not cause adverse perinatal outcome.

    Early human development·2015
    Same author

    Ovarian reserve and PGD treatment outcome in women with myotonic dystrophy.

    Reproductive biomedicine online·2014

    Area of Science:

    • Biochemistry
    • Hematology
    • Molecular Biology

    Background:

    • Sickle-cell disease is caused by abnormal hemoglobin S (Hb S).
    • The sickling phenomenon involves the formation of Hb S polymers.
    • The role of other hemoglobin types in this process is not fully understood.

    Purpose of the Study:

    • To investigate the participation of other hemoglobin species in the sickling process.
    • To determine how hemoglobins A, C, and F interact with Hb S polymers.

    Main Methods:

    • Direct analysis of the solid phase formed by deoxygenating Hb S solutions.
    • Inclusion of varying concentrations of hemoglobins A, C, and F in the solutions.

    Main Results:

    • Hemoglobins A and C were found to be incorporated into the filamentous structures of sickled cells.
    • Fetal hemoglobin (Hb F) was largely excluded from these Hb S polymers.
    • This differential incorporation suggests varying effects on sickling.

    Conclusions:

    • Hemoglobins A and C can modulate the sickling phenomenon by co-polymerizing with Hb S.
    • Hb F appears to inhibit or not participate in Hb S polymerization.
    • Understanding these interactions is crucial for developing targeted therapies for sickle-cell disease.

    Related Experiment Videos