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Serum enzyme activities after cardioversion.

T Mandecki, L Giec, W Kargul

    British Heart Journal
    |September 1, 1970
    PubMed
    Summary
    This summary is machine-generated.

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    Cardioversion can temporarily increase serum enzymes like SGOT and CPK, particularly after multiple DC shocks. This enzyme elevation likely originates from skeletal muscle and has no clinical significance for myocardial damage.

    Area of Science:

    • Biochemistry
    • Cardiology
    • Clinical enzymology

    Background:

    • Cardioversion is a medical procedure to restore normal heart rhythm.
    • Serum enzyme levels are often monitored post-cardioversion to assess potential organ damage.
    • Skeletal muscle and cardiac muscle share some enzymes, necessitating careful interpretation of results.

    Purpose of the Study:

    • To investigate changes in serum enzyme levels after cardioversion.
    • To determine the origin and clinical significance of post-cardioversion enzyme elevations.
    • To correlate enzyme changes with the number of direct current (DC) shocks administered.

    Main Methods:

    • Serum samples were collected from 94 patients before, 1.5 hours, and 24 hours after cardioversion.
    • Levels of aspartate aminotransferase (AST/SGOT), alanine aminotransferase (ALT/SGPT), creatinine phosphokinase (CPK), and butyric acid dehydrogenase (BDH) were measured.

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  • Patients were grouped based on the number of DC shocks received.

    • Main Results:

    • An increase in aspartate aminotransferase (SGOT) and creatinine phosphokinase (CPK) activity was observed 24 hours post-cardioversion.
    • This enzyme elevation was more pronounced in patients receiving two or more DC shocks.
    • No concurrent signs of myocardial damage were detected in the patient cohort.

    Conclusions:

    • Post-cardioversion increases in SGOT and CPK are likely due to skeletal muscle effects, not cardiac damage.
    • The observed enzyme changes following cardioversion, especially with multiple shocks, appear to have no clinical significance regarding myocardial injury.
    • Monitoring of these specific enzymes may not be critical for assessing cardiac health after cardioversion.