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[A specific fully enzymatic method for creatinine: reference values in serum (author's transl)].

U Börner, G Szász, W Bablok

    Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Fur Klinische Chemie Und Klinische Biochemie
    |November 1, 1979
    PubMed
    Summary

    New reference ranges for serum creatinine were established using a fully enzymatic method. These ranges differ significantly between men and women, with men showing higher creatinine concentrations up to age 60.

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    Area of Science:

    • Biochemistry
    • Clinical Chemistry
    • Analytical Chemistry

    Context:

    • Establishing accurate reference values for serum creatinine is crucial for diagnosing kidney function and related diseases.
    • Previous reference ranges may not fully account for demographic variations or utilize modern analytical methods.
    • A fully enzymatic method adapted to a discontinuous analyzer was employed for enhanced precision.

    Purpose:

    • To establish updated, reliable reference ranges for serum creatinine in adults using a modern enzymatic assay.
    • To investigate the influence of age and sex on serum creatinine concentrations within the adult population.
    • To provide sex-specific reference intervals for improved clinical interpretation.

    Summary:

    • Serum creatinine reference values were determined for 465 individuals (250 females, 215 males) aged 18-70 years.

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  • A fully enzymatic method on a discontinuous analyzer was utilized for precise creatinine measurement.
  • Creatinine levels showed no age dependency up to 60 years but differed significantly between sexes, with men having higher concentrations.
  • Impact:

    • The study proposes new sex-specific reference ranges for serum creatinine: 44-80 mu mol/l for women and 44-97 mu mol/l for men.
    • These updated ranges can enhance the accuracy of kidney function assessment and clinical decision-making.
    • The findings support the use of enzymatic methods for routine creatinine analysis in clinical laboratories.