Soluble HL-A7 antigen: localization in the beta-lipoprotein fraction of human serum

The HL-A7 antigen of human leukocytes occurs as a soluble, low-density lipoprotein in the serum of HL-A7-positive individuals. Its presence in high concentration may inhibit direct leukocyte grouping, leading to erroneous results. This finding affords an easy method for the preparation of monospecific cytotoxic antiserums by absorption with serum fractions rather than leukocytes.