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Exercise asthma and disodium cromoglycate.

H Poppius, A Muittari, K E Kreus

    British Medical Journal
    |November 7, 1970
    PubMed
    Summary
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    Disodium cromoglycate partially prevents exercise-induced asthma (EIA) in adults. Pre-exercise medication significantly reduced the fall in peak expiratory flow (PEF) after both maximal and submaximal exercise.

    Area of Science:

    • Pulmonary Medicine
    • Respiratory Physiology
    • Pharmacology

    Background:

    • Exercise-induced asthma (EIA) is a common condition characterized by bronchoconstriction following physical exertion.
    • Asthma management often involves strategies to mitigate exercise-induced symptoms.
    • Understanding the efficacy of prophylactic medications is crucial for patient care.

    Purpose of the Study:

    • To investigate the effect of disodium cromoglycate on exercise-induced bronchoconstriction in adult asthma patients.
    • To quantify the reduction in peak expiratory flow (PEF) following maximal and submaximal exercise with and without pre-treatment.

    Main Methods:

    • Study population: Adult patients with uncomplicated asthma.
    • Assessment of EIA: Defined as a fall in PEF ≥ 25% of the pre-exercise value.

    Related Experiment Videos

  • Intervention: Pre-exercise inhalation of disodium cromoglycate.
  • Exercise protocols: Maximal and submaximal (8 minutes) exercise.
  • Study designs: Open assessment (n=11) and double-blind crossover study (n=28).

    • Main Results:

    • Exercise-induced asthma occurred in 22 out of 52 adult patients.
    • Disodium cromoglycate reduced the mean PEF fall after maximal exercise from 50% to 23% (open assessment).
    • Disodium cromoglycate reduced the mean PEF fall after submaximal exercise from 18% to 10% (double-blind crossover).

    Conclusions:

    • Disodium cromoglycate demonstrates a partial inhibitory effect on exercise-induced airway resistance increase in asthma.
    • Prophylactic use of disodium cromoglycate can attenuate exercise-induced bronchoconstriction.
    • The findings support the use of disodium cromoglycate for managing EIA in susceptible individuals.