Related Experiment Video
Updated: Aug 5, 2026

Quantification of Coenzyme A in Cells and Tissues
Published on: September 27, 2019
[Duodenal lesions produced by pantothenic acid deficiency in animal experiments (author's transl)]
Abstract:
Inflammatory lesions of the duodenal mucosa and duodenal ulcers can be produced in animal experiments by pantothenic acid deficiency. We investigated this model in 30 rats of both sexes aged 2 or 6 months and 1 year. During 3 months the experimental animals were feeded with a diet including all the known nutritional factors except pantothenic acid, while the control animals received a standard diet. Thereafter paraffin and semithin sections of the duodenum showed mucosal changes and lesions (so-called Leistenspitzenerosionen, submucosal oedemas, initial duodenitis) in about three fourths of the experimental animals.--Yet there were no ulcers.--They, however, can be demonstrated when lengthening the experimental period as shown by our investigations using male rats aged 1 year (time for producing ulcers: approximate 5 months).--The duodenal lesions are typical and regularly to be reproduced. In this context their role as a precursor to an ulcer is discussed.
Related Concept Videos
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
Peptic Ulcer Disease I: Introduction
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Acute Pancreatitis I: Introduction
Chronic Pancreatitis I: Introduction
Chronic Pancreatitis II: Pathophysiology

