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Updated: Jul 14, 2026
09:29
Fabrication and Implantation of Miniature Dual-element Strain Gages for Measuring In Vivo Gastrointestinal Contractions in Rodents.
Published on: September 18, 2014
Summary
Vagotomy, a surgical procedure, increases gallbladder volume but does not alter its response to cholecystokinin. Bile composition may change long-term after vagotomy, though gallbladder structure remains consistent.
Area of Science:
- Gastroenterology
- Surgical Physiology
Background:
- Vagotomy is a surgical procedure involving the cutting of the vagus nerve.
- Gallbladder function is regulated by neural and hormonal factors, including the vagus nerve and cholecystokinin.
Purpose of the Study:
- To investigate the effects of vagotomy on gallbladder size, function, and bile composition.
- To evaluate the gallbladder's response to cholecystokinin (CCK) post-vagotomy.
Main Methods:
- Clinical radiological assessment of gallbladder volume and CCK response before and after vagotomy.
- Experimental studies in rabbits to assess immediate vagotomy effects on gallbladder pressure and CCK response.
- Long-term studies in cats examining gallbladder histology and bile composition after vagotomy.
Main Results:
- Clinical studies showed a significant increase in gallbladder volume post-vagotomy, with unchanged CCK response.
- Rabbit studies indicated altered gallbladder pressure response to CCK after vagotomy, with higher doses compensating.
- Cat studies suggested changes in bile chemical composition, but no significant histological changes in the gallbladder.
Conclusions:
- Vagotomy leads to gallbladder distension and altered bile composition.
- Gallbladder contractility response to CCK is modified by vagotomy, requiring higher doses for a similar effect.
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